Garcinia Cambogia – There might be something in this one….

Garcinia Cambogia – its about how you take it…

SGarcinia cambogia, is correctly known as the Malabar tamarind.  Its a small sweet fruit shaped like a pumpkin / squash. During the 60s,  an acid called Hydroxycitric Acid (HCA)  was discovered similar to citric acid found in oranges, grapefruits and lemons.

Like both Raspberry Ketones and African Mango, it is marketed as a miracle weight loss supplement, however like RK’s a lot of these results have only really been seen in rats.

About 5 years ago HCA’s popularity has steadily risen, like RK’s and it is quite usual for people to chat about “garcinia”, even my daughter has asked me: “Is garcinia for real?”

What is it actually doing?

HCA isn’t a miracle; it’s a tool. Anyone who has ever suffered the indignity of smashing their finger with another tool – the hammer – tools only work when you know what to do with them and then follow through on that knowledge.

However recently we’ve learned a lot about not only what HCA supplements do in the body, but also how you can make the most of them. Here’s what you need to know about this fat-loss supplement.

HCA’s Initial Claims

HCA got its first taste of widespread popularity back in the ’90s, after a number of studies concluded that it caused weight loss in animals. One thing we know is that HCA blocks a portion of an enzyme called citrate lyase, which helps turn sugars and carbs into fat.

Block that enzyme, and carbohydrates get diverted into energy production rather than accumulating as body fat. Then, when you burn fat through effective training, there’s less to replace it, and your overall fat level goes down.

HCA also seems to have an ability to help suppress the appetite, but not in the same way as a stimulant-based diet pill. Rather, it increases the level of satisfaction you receive from food, which makes it easier to eat less. How it does this isn’t entirely clear yet.   It may be that a metabolic change brought on by HCA may send an appetite-suppressing signal to the brain via the amino acid 5-hydroxytryptophan, which is a direct precursor to the so-called “happy hormone,” serotonin. Given that subsequent studies have shown elevated serotonin levels in subjects who took HCA supplements, this may be what is happening, although it remains scientifically unproven.

With these two things in its favour, HCA seemed on the verge of the big time, but the buzz faded quickly after a large study published in 1998 in the Journal of the American Medical Association concluded that it had “no effect” on human subjects.[1]

Job done, supplement debunked, right? Not quite. Subsequent research has produced some very different conclusions and helped convince me, among many other previously skeptical people, that HCA has real potential as a weight-loss supplement.

It’s All About How You Take It

A few years after the lackluster results in the above study, a guy called Harry Preuss, a researcher and pathologist at Georgetown University, saw enough to like about HCA to keep researching it after its popularity had waned.   He decided to take a closer look.

“You have to take the right dose of the right product, and you have to take it properly.  In the JAMA study, they used whatever the dose was at the time, and they never even mentioned the type of citrate they used. You have to give enough so that it reaches the sites in the body that it needs to reach.”

In recent years, Dr. Preuss has continued to hammer on the idea that maximizing bioavailability with HCA is crucial for its success.   Dr. Preuss, who went on to lead the most promising human studies into HCA, points out that there are three different forms of hydroxycitrates: those which are blended with calcium, potassium, or magnesium salts. The reason to add these salts is to decrease the degradation of free HCA into HCA lactone, an inactive form of the compound. These salts, which are added at a 1-to-1 or higher ratio in most commercial HCA supplements, also help your body more easily absorb the hydroxycitrate.

“If you have almost a pure calcium hydroxycitrate, it’s just not going to work,” he told me. He said he prefers hydroxycitrate that is bound to both calcium and potassium; he says the bond dramatically increases the absorption and effectiveness of HCA.

Dr. Preuss and his colleagues put this premise to the test in a study where they followed 30 healthy but overweight people ages 21-50 over an 8-week period.[2] All of the subjects consumed a diet of 2,000 calories per day and walked for half an hour five days per week. One group was given Super CitriMax, a patented form of HCA bound with both calcium and potassium. The other group was given a placebo. At the end of the study, the placebo group had lost an average of three pounds, but the HCA group had lost an average of 12 pounds—a whopping 400 percent more weight. Their average BMI fell by 6.3 percent; in the placebo group, it fell only 1.7 percent.

To top it off, the HCA group experienced an almost double boost in serotonin levels compared to the placebo group. Higher serotonin levels are associated with fewer cravings, as well as a greater sense of calm. In a second similar study, Preuss and his colleagues tested 60 people, and this time, the HCA group lost an average of 10.5 pounds compared to the placebo group, which lost an average of 3.5 pounds.[3]

“Perhaps the most remarkable result was in appetite control,” Preuss says of the second study. “The placebo group had no change, but the HCA group had a 16 percent reduction in the amount of food they ate per meal!”

The Right Way To Supplement With HCA

It’s far too easy to view supplements purely from the perspective of either “I take it” or “I don’t take it.” With some supplements, that’s precise enough to see an effect. But the lesson here is that how you take HCA matters. As such, Preuss has taken the new wave of HCA popularity as an opportunity to remind us all about how to get the most out of this supplement, most recently in a paper he co-authored for the Alliance for Natural Health in 2013 titled “Garcinia Cambogia: How to Optimize its Effects.”[4]

Here are Preuss’ recommendations:

  • Choose a preparation that is at a minimum 50 percent HCA and is not composed wholly of calcium salts: Make sure potassium (K) and/or magnesium (Mg) is present. If the product has a low lactone content, that is even better.
  • Be sure to take an adequate dose. For a Ca/K preparation used successfully and reported in a peer-reviewed publication, the dose of extract was near 1.5g, three times per day before meals. In this 60 percent HCA preparation, that approximates 0.9 g of HCA prior to each meal.
  • Take the preparation on an empty stomach, i.e., 30-60 minutes before each meal.
  • Remember, “If you don’t comply, don’t complain.” Take the right dose at the right time.

Note that he says “near” 1.5 g three times daily. Why not exactly 1.5? Given that HCA supplements come in a range of potencies and mixtures, it can be hard to be exact. Aim for the 1.5 g benchmark, but don’t be obsessive.  Why on an empty stomach? It takes advantage of the appetite-curbing effect of the supplement, but even more important, HCA needs some space to work its magic.

“In the presence of food, the hydroxycitrate salt can bind to some of the components in the meal and be inactivated,” Preuss writes. “This is called the ‘food effect’ and can seriously reduce the bioavailability of a number of supplements, not just HCA.”

Follow these guidelines, and HCA can be an addition to your arsenal. Side effects are rare at the kind of reasonable doses that Preuss recommends, and since it’s not a stimulant, you don’t need to worry about it affecting your sleep or mood. If you’re looking to control your weight and are committed to eating right and working out, don’t be afraid to add this popular supplement into the mix!

So there you go there may actually be something in this for once.  However don’t just go out and buy any old Garcinia Cambogia supp, make sure it is as shown above.  But  remember this is not a miracle, and is no substitute for hard work in the gym.

Dr Vee.


Heymsfield SB, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. 1998 Nov 11;280(18):1596-600.
Preuss HG, et al. Efficacy of a novel, natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX, niacin-bound chromium and Gymnema sylvestre extract in weight management in human volunteers: a pilot study. Nutrition Research. 2004 Jan; 24(1); 45-58.
Preuss, HG, et al., Effects of a natural extract of (-)-hydroxycitric acid (CHA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab. 2004 May; 6(3): 171-80.
Preuss, HG and Dallas Clouatre. Garcinia cambogia: How to optimize its effects. Available from:

African Mango Extract – another crock!

African Mango, more hype, less losses

This one has a little more info and potentially basis than the previous post on Raspberry Ketones, as there is an extract from the African Mango (irvingia gabonensis) Seed (Also called Dika Nuts) that does have an effect on weight loss. However it is a very specific extract called IGOB131. Here are a couple of articles from the US National Library of Medicine (a US Government body):

However WebMD has stated that this research is of a poor quality, and one was also sponsored by a supp company I cant find a lot about – may be owned by Dr Oz :lol:, and was carried out on non-Western subjects, local to Cameroon, and on a pretty high cal diet 2700 cals+, which may be skewing the results.

Also as this is pushed by Dr Oz, you can almost bet that it is snake oil again.

What I am also struggling in finding out whether the products the are being pedalled actually contain any IGOB131, and if so whether this is enough to trigger the effects described in this article.

The Claims

The sites I have found for the supplement version make the following claims, as they all seem to:



– SHED INCHES FROM WAISTLINE (well you’re losing weight so this is a given surely – bloody marketing hype)



These claims seem to have some basis (to the extent of the research trials), however until this is ratified with a wider level of independent research it is really difficult to draw a full conclusion.

For obesity and lowering cholesterol levels, a dose of 1.05 grams of crude seed extract three times daily has been used. A dose of 150 mg of a standardized seed extract (IGOB131) twice or three times daily has also been used.  However most of the supps I have seen are not this, they are just African Mango extract, which is probably not the stuff you actually need.  I also have it on first hand authority that having been tried by a colleague I trust, it proved to do Zero when taken as directed, with no other changes to diet.

What is happening

Most of these products work as subconsciously people modify their diet when taking it.  they think they wont have they extra biscuit or slice of cake as they are taking a diet pill.  Any losses are then from the dietary changes, not the pill.

If considering using this stuff, consider the following:

A/. All research has used IGOB131 ONLY. You should look for the quantity of IGOB131 on the label, if its not mentioned…. well you decide. If it contains whole African mango or different extracts it wont have then same effects.

B/. Based on the research best results happen when people take 450 mg of IGOB131 as day (3 x 150mg). Good results will be better when combined with a lower calorie diet (no shit Sherlock)

C/. Weight loss alone could account for the observed changes in total cholesterol and LDL and CRP. Some have attributed the effects of African Mango to its soluble fibre content but I think this may be premature, as personally mine dropped when I lost my fat.

D/. One study showed that Irvingia Gabonensis lowered leptin levels, and this is being used incorrectly as a justification for weight loss. When Leptin is lowered, your appetite increases, so is counter to what is being suggested by the hype. Low leptin is a bugger, and can lead to cravings. I am trying a leptin modifying diet at the moment, that promoted higher leptin in the mornings, and the effect on my cravings has been great. I wouldn’t want low leptin levels.


So as I said I am really not sure on this one. It has been around a while, but gaining popularity through Dr Mehmet ‘Snake Oil’ Oz. This will mean that as supplies are harder to come by, different extracts are bound to be used rather than the one that is key. This has been seen before with Synephrine and Bitter Orange Extract.

Best bet is to just sort out your diet and train more…


Next Up: Garcinia Cambogia….. Stay tuned.

Dr Vee.